What is insane in the membrane?

Insane in the Membrane is a song by the American hip-hop group Cypress Hill. It was released in 1993 as a single from their album Black Sunday. The song features a prominent sample from the hit 1970 song "Son of a Preacher Man" by Dusty Springfield.

The lyrics of the song are a combination of nonsense phrases and references to smoking marijuana and achieving a state of euphoria. The chorus, "Insane in the membrane, insane in the brain" became a popular catchphrase in the 1990s.

Despite the controversial subject matter, the song was a commercial success, reaching number 19 on the US Billboard Hot 100 chart and becoming a staple in the group's live performances. It has been covered by numerous artists and has been featured in several films and TV shows.